Endophytic fungi in economically important plants: ecological aspects, diversity and potential biotechnological applications

Beatriz dos Santos Souza, Taides Tavares dos Santos


The aim of the present study was to perform a review of the literature to provide a brief overview of the ecological aspects, diversity and potential biotechnological applications of endophytic fungi associated with economically important plants, such as the common bean (Phaseolus vulgaris), cocoa (Theobroma cacao) and soybean (Glycine max). A high diversity of fungi has been reported on the leaves, stems and other organs of such plants. Studies on this subject are of considerable importance and directly contribute to the knowledge and conservation of fungal biodiversity, especially in Neotropical areas. Furthermore, such studies can open the door to a wide range of potential uses and/or modulations of fungal microbiota with the aim of enhancing the health and productivity of plants in agricultural practices, such as promoting plant growth or the biological control of diseases caused by phytopathogenic microorganisms. These endophytic fungi also represent a valuable source for prospecting secondary metabolites for biotechnological purposes.


biotechnology; biological control; symbiotic interactions; secondary metabolites; plant growth promotion

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ALMEIDA, C.V.; YARA, R.; ALMEIDA, M. Fungos endofíticos isolados de ápices caulinares de pupunheira cultivada in vivo e in vitro. Pesquisa Agropecuaria Brasileira, v. 40, n. 5, p. 467–470, 2005.

AMARAL, L.S.; RODRIGUES-FILHO, E. Two novel eremophilane sesquiterpenes from an endophytic Xylariaceous fungus isolated from leaves of Cupressus lusitanica. Journal of the Brazilian Chemical Society, v. 21, n. 8, p. 1446-1450, 2010.

ARAÚJO, W.L.; MACCHERONI, W.; AGUILAR-VILDOSO, C.I.; BARROSO, P.A.; SARIDAKIS, H.O.; AZEVEDO, J.L. Variability and interactions between endophytic bacteria and fungi isolated from leaf tissues of citrus rootstocks. Canadian Journal of Microbiology, v. 47, n. 3, p. 229–236, 2001.

ARNOLD, A.E.; MEJIA, L.C.; KYLLO, D.; ROJAS, E.I.; MAYNARD, Z.; ROBBINS, N.; HERRE, E.A. Fungal endophytes limit pathogen damage in a tropical tree. Proceedings of the National Academy of Sciences (PNAS), v. 100, n. 26, p. 15649-15654, 2003.

ARNOLD, A.E.; MAYNARD, Z.; GILBERT, G.S. Fungal endophytes in dicotyledonous neotropical trees: patterns of abundance and diversity. Mycological Research, v. 105, n. 12, p. 1502–1507, 2001.

AZEVEDO, J.L.; MACCHERONI JUNIOR, W.; PEREIRA, J.O.; ARAÚJO, W.L. Endophytic microorganisms: a review on insect control and recent advances on tropical plants. Electronic Journal of Biotechnology, v. 3, n. 1, 40-65, 2000.

BAE, H.; SICHER, R.C.; KIM, M.S.; KIM, S.H.; STREM, M.D.; MELNICK, R.L.; BAILEY, B.A. The beneficial endophyte Trichoderma hamatum isolate DIS 219b promotes growth and delays the onset of the drought response in Theobroma cacao. Journal of Experimental Botany, v. 60, n. 11, p. 3279–3295, 2009.

BAILEY, B.A.; BAE, H.; STREM, M.D.; CROZIER, J.; THOMAS, S.E.; SAMUELS, G.J.; VINYARD, B.T.; HOLMES, K.A. Antibiosis, mycoparasitism, and colonization success for endophytic Trichoderma isolates with biological control potential in Theobroma cacao. Biological Control, v. 46, p. 24–35, 2008.

BARA, R.; ALY, A.H.; WRAY, V.; LIN, W.; PROKSCH, P.; DEBBAB, A. Talaromins A and B, new cyclic peptides from the endophytic fungus Talaromyces wortmannii. Tetrahedron Letters, v. 54, n. 13, p. 1686–1689, 2013.

BRAGA, G.U.L.; DESTÉFANO, R.H.R.; MESSIAS, C.L. Protease production during growth and autolysis of submerged Metarhizium anisopliae cultures. Revista de Microbiologia, v. 30, n. 2, p. 107-113, 1999.

BUDHIRAJA, A.; NEPALI, K.; SAPRA, S.; GUPTA, S.; KUMAR, S.; DHAR, K.L. Bioactive metabolites from an endophytic fungus of Aspergillus species isolated from seeds of Gloriosa superba Linn. Medicinal Chemistry Research, v. 22, n. 1, p. 323–329, 2013.

CABRAL, D.; STONE, J.K.; CARROLL, G.C. The internal mycobiota of Juncus spp.: microscopic and cultural observations of infection patterns. Mycological Research, v. 97, n. 3, p. 367-376, 1993.

CAFÊU, M.C.; SILVA, G.H.; TELES, H.L.; BOLZANI, V.S.; ARAÚJO, A.R.; YOUNG, M.C.M.; PFENNING, L.H. Substâncias antifúngicas de Xylaria sp., um fungo endofítico isolado de Palicourea marcgravii (Rubiaceae). Química Nova, v. 28, n. 6, p. 991-995, 2005.

CAMPOS, F.F.; SALES JÚNIOR, P.A.; ROMANHA, A.J.; ARAÚJO, M.S.S.; SIQUEIRA, E.P.; RESENDE, J.M.R.; ALVES, T.M.A.; MARTINS-FILHO, A.O.; SANTOS, V.L.; ROSA, C.A.; ZANI, C.L.; COSTA, B.B. Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as atrypanocidal metabolite from Fusarium sp. Memórias do Instituto Oswaldo Cruz, v. 110, p. 65-74, 2015.

CAO, R.; LIU, X.; GAO, K.; MENDGEN, K.; KANG, Z.; GAO, J.; DAI, Y.; WANG, X. Mycoparasitism of endophytic fungi isolated from reed on soilborne phytopathogenic fungi and production of cell wall–degrading enzymes in vitro. Current Microbiology, v. 59, p. 584–592, 2009.

CHEN, Z.; CHEN, H.P.; LI, Y.; FENG, T.; LIU, J.K. Cytochalasins from cultures of endophytic fungus Phoma multirostrata EA-12. The Journal of Antibiotics, v. 68, p. 23-16, 2015.

CLARKE, B.B.; WHITE JR, J.F.; HURLEY, R.H.; TORRES, M.S.; SUN, S.; HUFF, D.R. Endophyte-mediated suppression of dollar spot disease in fine fescues. Plant Disease, v. 90, p. 994–998, 2006.

CONTI, R.; GUIMARÃES, D.O.; PUPO, M.T. Aprendendo com as interações da natureza: microrganismos simbiontes como fontes de produtos naturais bioativos. Ciência e Cultura, v. 64, n. 3, p. 43-47, 2012.

CRAWFORD, K.M.; LAND, J.M.; RUDGERS, J.A. Fungal endophytes of native grasses decrease insect herbivore preference and performance. Oecologia, v. 164, n. 2, p. 431–444, 2010.

CROZIER, J.; THOMAS, S. E.; AIME, M.C.; EVANS, H.C.; HOLMES, K.A. Molecular characterization of fungal endophytic morphospecies isolated from stems and pods of Theobroma cacao. Plant Pathology, v. 55, n. 6, p. 783–791, 2006.

FÁVARO, L.C.L.; SEBASTIANES, F.L.S.; ARAÚJO, W.L. Epicoccum nigrum P16, a sugarcane endophyte, produces antifungal compounds and induces root growth. Plos One, v. 7, n. 6, p. 1–10, 2012.

FERNANDES, M.R.V.; SILVA, T.A.C.; PFENNING, L.H.; COSTA-NETO, C.M.; HEINRICH, T.A.; ALENCAR, S.M.; LIMA, M.A.; IKEGAKI, M. Biological activities of the fermentation extract of the endophytic fungus Alternaria alternata isolated from Coffea arabica L. Brazilian Journal of Pharmaceutical Sciences, v. 45, n. 4, p. 677-685, 2009.

FERNANDES, E.G.; PEREIRA, O.L.; SILVA, C.C.; BENTO, C.B.P.; QUEIROZ, M.V. Diversity of endophytic fungi in Glycine max. Microbiological Research, v. 181, p. 84–92, 2015.

FERREIRA, M.C.; VIEIRA, M.L.A.; ZANI, C.Z.; ALVES, T.M.A.; SALES JUNIOR, P.A.; MURTA, S.M.F.; ROMANHA, A.J.; GIL, L.H.V.G.; CARVALHO, A.G.O.; ZILLI, J.E.; VITAL, M.J.S.; ROSA, C.A.; ROSA, L.H. Molecular phylogeny, diversity, symbiosis and discover of bioactive compounds of endophytic fungi associated with the medicinal Amazonian plant Carapa guianensis Aublet (Meliaceae). Biochemical Systematics and Ecology, v. 59, p. 36-44, 2015.

FISHER, P.J.; PETRINI, O.; SCOTT, H.M.L. The distribution of some fungal and bacterial endophytes in Maize (Zea mays L). New Phytologist, v. 122, p. 299–305, 1992.

GANGADEVI, V.; MUTHUMARY, J. Taxol production by Pestalotiopsis terminaliae, an endophytic fungus of Terminalia arjuna (arjun tree). Biotechnology and Applied Biochemistry, v. 52, p. 9–15, 2009.

GANGE, A.C.; ESCHEN, R.; WEARN, J.A.; THAWER, A.; SUTTON, B.C. Differential effects of foliar endophytic fungi on insect herbivores attacking a herbaceous plant. Oecologia, v. 168, n. 4, p. 1023–1031, 2012.

GAO, F.; DAI, C.; LIU, X. Mechanisms of fungal endophytes in plant protection against pathogens. African Journal of Microbiology Research, v. 4, n. 13, p. 1346–1351, 2010.

GAO, X.X.; ZHOU, H.; XU, D.-Y.; YU, C.-H.; CHEN, Y.-Q.; QU, L.-H. High diversity of endophytic fungi from the pharmaceutical plant, Heterosmilax japonica Kunth revealed by cultivation-independent approach. FEMS Microbiology Letters, v. 249, p. 255-266, 2005.

GAROÉ, N.; CABRERA, R.; LISBEL, B.R.; EVELYN, D.S.; ANDREEA, C.; NÉLIDA, B. Endophytic fungi from Vitis vinifera L. isolated in Canary Islands and Azores as potential biocontrol agents of Botrytis cinerea Pers.: Fr. Journal of Horticulture, Forestry and Biotechnology, v. 16, n. 1, p. 1–6., 2012.

GAZIS, R.; CHAVERRI, P. Diversity of fungal endophytes in leaves and stems of wild rubber trees (Hevea brasiliensis) in Peru. Fungal Ecology, v. 3, n. 3, p. 240–254, 2010.

GONZAGA, L.L.; COSTA, L.E.; SANTOS, T.T.; ARAÚJO, E.F.; QUEIROZ, M.V. Endophytic fungi from the genus Colletotrichum are abundant in the Phaseolus vulgaris and have high genetic diversity. Journal of Applied Microbiology, v. 118, p. 485–496, 2014.

GRIGOLETTI JUNIOR, A.; SANTOS, A.F.; AUER, C.G. Perspectivas do uso do controle biológico contra doenças florestais. Floresta, v. 30, p. 155-165, 2000.

HAMAYUN, M.; KHAN, S.; AHMAD, N.; TANG, D.S.; KANG, S.M.; NA, C.I.; SOHN, E.Y.; HWANG, Y.H.; SHIN, D.H.; LEE, B.H.; KIM, J.G.; LEE, I.J. Cladosporium sphaerospermum as a new plant growth-promoting endophyte from the roots of Glycine max (L.). Merr. World Journal Microbiology and Biotechnology, v. 25, n. 4, p. 627-632, 2009a.

HAMAYUN, M.; KHAN, S.A.; KIM, H.Y.; CHAUDHARY, M.F.; HWANG, Y.H.; SHIN, D.H.; KIM, I.K.; LEE, B.H.; LEE, I.J. Gibberellin production and plant growth enhancement by newly isolated strain of Scolecobasidium tshawytschae. Journal of Microbiology and Biotechnology, v. 19, n. 6, p. 560-565, 2009b.

HANADA, R.E.; JORGE SOUZA, T.; POMELLA, A.W.V.; HEBBAR, K.P.; PEREIRA, J.O.; ISMAIEL, A.; SAMUELS, G.J. Trichoderma martiale sp. nov., a new endophyte from sapwood of Theobroma cacao with a potential for biological control. Mycological Research, v. 112, p. 1335–1343, 2008.

HANADA, R.E.; POMELLA, A.W.V.; COSTA, H.S.; BEZERRA, J.L.; LOGUERCIO, L.L.; PEREIRA, J.O. Endophytic fungal diversity in Theobroma cacao (cacao) and T. grandiflorum (cupuaçu) trees and their potential for growth promotion and biocontrol of black-pod disease. Fungal Biology, v. 114, p. 901–910, 2010.

HORN, W.S.; SIMMONDS, M.S.J.; SCHWARTZ, R.E.; BLANEY, W.M. Phomopsichalasin, a novel antimicrobial agent from an endophytic Phomopsis sp. Tetrahedron, v. 51, n. 14, 3969–3978, 1995.

HYDE, K.D.; SOYTONG, K. The fungal endophyte dilemma. Fungal Diversity, v. 33, p. 163-173, 2008.

KHAN, A.L.; HAMAYUN, M.; AHMAD, N.; HUSSAIN, J.; KANG, S.M.; KIM, Y.H.; ADNAN, M.; TANG, D.S.; WAQAS, M.; RADHAKRISHNAN, R.; HWANG, Y.H.; LEE, I.J. Salinity Stress Resistance Offered by Endophytic Fungal Interaction Between Penicillium minioluteum LHL09 and Glycine max. L. Journal of Microbiology and Biotechnology, v. 21, p. 893–902, 2011.

KHAN, A.R.; ULLAH, I.; WAQAS, M.; SHAHZAD, R.; HONG, S.-J.; PARK, G.-S.; JUNG, B.K.; LEE, I.-J.; SHIN, J.-H. Plant growth-promoting potential of endophytic fungi isolated from Solanum nigrum leaves. World Journal of Microbiology and Biotechnology, v. 31, n. 9, p. 1461–1466, 2015.

KUMAR, S.; KAUSHIK, N. Metabolites of endophytic fungi as novel source of biofungicide: a review. Phytochemistry Review, v. 11, p. 507–522, 2012.

KUMAR, S.; KAUSHIK, N. Endophytic Fungi Isolated from Oil-Seed Crop Jatropha curcas Produces Oil and Exhibit Antifungal Activity. Plos One, v. 8, n. 2, p. 1-8, 2013.

KUMAR, V.; SAHAI, V.; BISARIA, V.S. High-density spore production of Piriformospora indica, a plant growth-promoting endophyte, by optimization of nutritional and cultural parameters. Bioresource Technology, v. 102, p. 3169–3175, 2011.

KUMAR, S.; UPADHYAY, R.; AHARWAL, R.P.; SANDHU, S.S. Antibacterial activity of some isolated endophytic fungi from Menthe viridis. International Journal of Applied Biology and Pharmaceutical Technology, v. 7, n. 1, p. 239–249, 2016.

LARRAN, S.; PERELLO, A.; SIMON, M.R.; MORENO, V. The endophytic fungi from wheat (Triticum aestivum L.). World Journal Microbiology and Biotechnology, v. 23, p. 565-572, 2007.

LAZZARETTI, E.; BETTIOL, W. Tratamento de sementes de arroz, trigo, feijão e soja com um produto formulado à base de células e de metabólitos de Bacillus subtilis. Scientia Agricola, v. 54, p. 89-96, 1997.

LEITE, T.S.; CNOSSEN-FASSONI, A.; PEREIRA, O.L.; MIZUBUTI, E.S.G.; ARAÚJO, E.F.; QUEIROZ, M.V. Novel and Highly Diverse Fungal Endophytes in Soybean Revealed by the Consortium of Two Different Techniques. Journal of Microbiology, v. 51, n. 1, p. 56–69, 2013.

LEME, A.C.; BEVILAQUA, M.R.R.; RHODEN, S.A.; MANGOLIN, C.A.; MACHADO, M.F.P.S.; PAMPHILE, J.A. Molecular characterization of endophytes isolated from Saccharum spp based on esterase and ribosomal DNA (ITS1-5.8S-ITS2) analyses. Genetics and Molecular Research, v. 12, n. 3, p. 4095–105, 2013.

LUZ, J.S.; SILVA, R.L.O.; SILVEIRA, E.B.; CAVALCANTE, U.M.T. Atividade enzimática de fungos endofíticos e efeito na promoção do crescimento de mudas de maracujazeiro-amarelo. Revista Caatinga, v. 19, n. 2, p. 128-134, 2006.

MARIANO, R.L.R.; SILVEIRA, E.B.; ASSIS, S.M.P.; GOMES, A.M.A.; NASCIMENTO, A.R.P.; DONATO, V.M.T.S. Importância de bactérias promotoras de crescimento e de biocontrole de doenças de plantas para uma agricultura sustentável. Anais da Academia Pernambucana de Ciência Agronômica, v. 1, p. 89-111, 2004.

MARINHO, A.M.R.; MARINHO, P.S.B.; RODRIGUES FILHO, E. Esteroides produzidos por Penicillium herquei, um fungo endofítico isolado dos frutos de Melia azedarach (Meliaceae). Química Nova, v. 32, n. 7, p. 1710-1712, 2009.

MEISTER, B.; KRAUSS, J.; HÄRRI, S.A.; SCHNEIDER, M.V.; MULLER, C.B. Fungal endosymbionts affect aphid population size by reduction of adult life span and fecundity. Basic and Applied Ecology, v. 7, p. 244- 252, 2006.

MEJÍA, L.C.; ROJAS, E.I.; MAYNARD, Z.; BAEL, S.V.; ARNOLD, A.E.; HEBBAR, P.; SAMUELS, G.J.; ROBBINS, N.; HERRE, E.A. Endophytic fungi as biocontrol agents of Theobroma cacao pathogens. Biological Control, v. 46, p. 4–14, 2008.

MOMESSO, L.S.; KAWANO, C.Y.; RIBEIRO, P.H.; NOMIZO, A.; GOLDMAN, G.H.; PUPO, M.T. Chaetoglobosinas produzidas por Chaetomium globosum, fungo endofítico associado a Viguiera robusta Gardn. (Asteraceae). Química Nova, v. 31, n. 7, p. 1680-1685, 2008.

MORANDI, M.A.B.; BETTIOL, W. Controle biológico de doenças de plantas no Brasil. In: BETTIOL, W.; MORANDI, M.A.B. (Ed.) Biocontrole de doenças de plantas: uso e perspectivas. Embrapa Meio Ambiente, 2009, 341 p.

MORENO, E.; VARUGHESE, T.; SPADAFORA, C.; ARNOLD, E.; COLEY, P.D.; KURSAR, T.A.; GERWICK, W.H.; CUBILLA-RIOSA, L. Chemical Constituents of the New Endophytic Fungus Mycosphaerella sp. nov. and Their Anti-Parasitic Activity. Natural Product Communications, v. 6, p. 835-840, 2011.

MÜLLER, C.B.; KRAUSS, J. Symbiosis between grasses and asexual fungal endophytes. Current Opinion in Plant Biology, v. 8, n. 4, p. 450-456, 2005.

MUSSI-DIAS, V.; ARAÚJO, A.C.O.; SILVEIRA, S.F.; ROCABADO, J.M.A.; ARAÚJO, K.L. Fungos endofíticos associados a plantas medicinais. Revista Brasileira de Plantas Medicinais, v. 14, n. 2, p. 261-266, 2012.

NAIK, B.S.; SHASHIKALA, J.; KRISHNAMURTHY, Y.L. Study on the diversity of endophytic communities from rice (Oryza sativa L.) and their antagonistic activities in vitro. Microbiological Research, v. 164, n. 3, p. 290–296, 2009.

NISA, H.; KAMILI, A.N.; NAWCHOO, I.A.; SHAFI, S.; SHAMEEM, N.; BANDH, S.A. Fungal endophytes as prolific source of phytochemicals and other bioactive natural products: A review. Microbial Pathogenesis, v. 82, p. 50–59, 2015.

OKI, Y.; SOARES, N.; BELMIRO, M.S.; CORRÊA JR., A.; FERNANDES, G.W. Influência dos fungos endofíticos sobre os herbívoros de Baccharis dracunculifolia (Asteraceae). Neotropical Biology and Conservation, v. 4, n. 2, p. 83-88, 2009.

OROLE, O.O.; ADEJUMO, T.O. Bacterial and fungal endophytes associated with grains and roots of maize. Journal of Ecology and The Natural Environment, v. 3, p. 298-303, 2011.

OWNLEY, B.H.; GWINN, K.D.; VEGA, F.E. Endophytic fungal entomopathogens with activity against plant pathogens: ecology and evolution. BioControl, v. 55, p. 113–128, 2010.

PANCHER, M.; CEOL, M.; CORNEO, P.E.; LONGA, C.M.O.; YOUSAF, S.; PERTOT, I.; CAMPISANO, A. Fungal endophytic communities in grapevines (Vitis vinifera L.) Respond to crop management. Applied and Environmental Microbiology, v. 78, n. 12, p. 4308–4317, 2012.

PEIXOTO NETO, P.A.S.; AZEVEDO, J.L.; ARAÚJO, W.L. Microrganismos endofíticos. Biotecnologia Ciência & Desenvolvimento, v. 29, p. 62-77, 2002.

PEREIRA, J.; VIEIRA, M.; AZEVEDO, J. Endophytic fungi from Musa acuminata and their reintroduction into axenic plants. World Journal of Microbiology and Biotechnology, v. 15, p. 37–40, 1999.

PETRINI, O. Fungal endophytes of tree leaves. In: Andrews, J.H.; Hirano, S.S. (eds.) Microbial ecology of leaves. New York: Spring-Verlag, 1991, p. 179-197.

PIMENTEL, I.C.; GLIENKE-BLANCO, C.; GABARDO, J.; STUART, R.M.; AZEVEDO, J.L. Identification and colonization of endophytic fungi from soybean (Glycine max (l.) merril) under different environmental conditions. Brazillian Archives of Biology and Technology, v. 49, n. 5, p. 705-711, 2006.

RAPS, A.; VIDAL, S. Indirect effects of an unspecialized endophytic fungus on specialized plant – herbivorous insect interactions. Oecologia, v. 114, p. 541-547, 1998.

REDMAN, R.S.; SHEEHAN, K.B.; STOUT, T.G.; RODRIGUEZ, R.J.; HENSON, J.M. Thermotolerance generated by plant/fungal symbiosis. Science, v. 298, p. 1581, 2002.

REKHA, D.; SHIVANA, M.B. Diversity, antimicrobial and antioxidant activities of fungal endophytes in Cynodon dactylon (L.) Pers. and Dactyloctenium aegyptium (L.) P. Beauv. International Journal of Current Microbiology and Applied Science, v. 3, n. 8, p. 573-591, 2014.

ROCHA, A.C.S.; GARCIA, D.; UETANABARO, A.P.T.; CARNEIRO, R.T.O.; ARAÚJO, I.S.; MATTOS, C.R.R.; GÓES-NETO, A. Foliar endophytic fungi from Hevea brasiliensis and their antagonism on Microcyclus ulei. Fungal Diversity, v. 47, p. 75–84, 2011.

RODRIGUES, A.A.C.; MENEZES, M. Detecçao de fungos endofíticos em sementes de caupi provenientes de Serra Talhada e de Caruaru, Estado do Pernambuco. Fitopatologia Brasileira, v. 27, n. 5, p. 532–537, 2002.

RODRIGUEZ, R.J.; WHITE JUNIOR, J.F.; ARNOLD, A.E.; REDMAN, R.S. Fungal endophytes: diversity and functional roles. The New Phytologist, v. 182, n. 2, p. 314–330, 2009.

RÖNSBERG, D.; DEBBAB, A.; MÁNDI, A.; WRAY, V.; DAI, H.; KURTÁN, T.; PROKSCH, P.; ALY, A.H. Secondary metabolites from the endophytic fungus Pestalotiopsis virgatula isolated from the mangrove plant Sonneratia caseolaris. Tetrahedron Letters, v. 54, n. 25, p. 3256–3259, 2013.

RUBINI, M.R.; SILVA-RIBEIRO, R.T.; POMELLA, A.W.V.; MAKI, C.S.; ARAÚJO, W.L.; SANTOS, D.R.; AZEVEDO, J.L. Diversity of endophytic fungal community of cacao (Theobroma cacao L.) and biological control of Crinipellis perniciosa, causal agent of Witches’ Broom Disease. International Journal of Biological Sciences, v. 1, p. 24-33, 2005.

SADRATI, N.; DAOUD, H.; ZERROUG, A.; DAHAMNA, S.; BOUHARATI, S. Screening of antimicrobial and antioxidant secondary metabolites from endophytic fungi isolated from wheat (Triticum durum). Journal of Plant Protection Research, v. 53, n. 2, p. 128–136, 2013.

SANTAMARÍA, J.; BAYMAN, P. Fungal epiphytes and endophytes of coffee leaves (Coffea arabica). Microbial Ecology, v. 50, p. 1-8, 2005.

SANTOS, T.T.; LEITE, T.S.; QUEIROZ, C.B.; ARAÚJO, E.F.; PEREIRA, O.L.; QUEIROZ, M.V. High genetic variability in endophytic fungi from the genus Diaporthe isolated from common bean (Phaseolus vulgaris L.) in Brazil. Journal of Applied Microbiology, v. 120, n. 2, p. 388–401, 2016.

SETTE, L.D.; PASSARINI, M.R.Z.; DELARMELINA, C.; SALATI, F.; DUARTE, M.C.T. Molecular characterization and antimicrobial activity of endophytic fungi from coffee plants. World Journal Microbiology and Biotechnology, v. 22, p. 1185–1195, 2006.

SILVA, G.H.; OLIVEIRA, C.M.; TELES, H.L.; BOLZANI, V.S.; ARAUJO, A.R.; PFENNING, L.H.; YOUNG, M.C.M.; COSTA-NETO, C.M.; HADDAD, R.; EBERLIN, M.N. Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae). Química Nova, v. 33, n. 10, p. 2038-2041, 2010.

SOUZA, A.Q.L.; SOUZA, A.D.L.; ASTOLFI FILHO, S.; BELÉM PINHEIRO, M.L.; SARQUIS, M.I.M.; PEREIRA, J.O. Atividade antimicrobiana de fungos endofíticos isolados de plantas tóxicas da amazônia: Palicourea longiflora (aubl.) rich e Strychnos cogens bentham. Acta Amazônica, v. 34, n. 2, p. 185-195, 2004.

SREEKANTH, D.; SYED, A.; SARKAR, S.; SARKAR, D.; SANTHAKUMARI, B.; AHMAD, A.; KHAN, M.I. Production, purification, and characterization of Taxol and 10-DABIII from a new Endophytic Fungus Gliocladium sp. Isolated from the Indian Yew Tree, Taxus baccata. Journal of Microbiology and Biotechnology, v. 19, n. 11, p. 1342–1347, 2009.

STIERLE, A.; STROBEL, G.; STIERLE, D. Taxol and taxane production by taxomyces andreanae an endophytic fungus of Pacific yew. Science, v. 260, p. 214-216, 1993.

STROBEL, G.; DAISY, B. Bioprospecting for microbial endophytes and their natural products. Microbiology and Molecular Biology Reviews, v. 67, n. 4, p. 491-502, 2003.

STROBEL, G.; YANG, X.; SEARS, J.; KRAMER, R.; SIDHU, R.S.; HESS, W.M. Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana. Microbiology, v. 142, p. 435-440, 1996.

STROBEL, G.A.; DIRKSE, E.; SEARS, J.; MARKWORTH, C. Volatile antimicrobials from Muscodor albus, a novel endophytic fungus. Microbiology, v. 147, p. 2943–2950, 2001.

STROBEL, G.A.; MILLER, R.V.; MARTINEZMILLER, C.; CONDRON, M.M.; TEPLOW, D.B.; HESS, W.M. Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Microbiology, v. 145, p. 1919-1926, 1999.

STUART, R.M.; ROMÃO, A.S.; PIZZIRANI-KLEINER, A.A.; AZEVEDO, J.L.; ARAÚJO, W.L. Culturable endophytic filamentous fungi from leaves of transgenic imidazolinone-tolerant sugarcane and its non-transgenic isolines. Archives of Microbiology, v. 192, n. 4, p. 307–313, 2010.

SURYANARAYANAN, T.S.; THIRUNAVUKKARASU, N.; GOVINDARAJULU, M.B.; GOLAPAN, V. Fungal endophytes: an untapped source of biocatalysts. Fungal Diversity, v. 54, n. 1, p. 19–30, 2012.

SURYANARAYANAN, T.S.; THIRUNAVUKKARASU, N.; GOVINDARAJULU, M.B.; SASSE, F.; JANSEN, R.; MURALI, T.S. Fungal endophytes and bioprospecting. Fungal Biology Reviews, v. 23, p. 9–19, 2009.

TAKAHASHI, J.A.; LUCAS, E.M.F. Ocorrência e diversidade estrutural de metabólitos fúngicos com atividade antibiótica. Química Nova, v. 31, n. 7, p. 1807-1813, 2008.

TALONTSI, F.M.; DITTRICH, B.; SCHÜFFLER, A.; SUN, H.; LAATSCH, H. Epicoccolides: Antimicrobial and Antifungal Polyketides from an Endophytic Fungus Epicoccum sp. Associated with Theobroma cacao. European Journal of Organic Chemistry, v. 2013, n. 15, p. 3174–3180, 2013.

VARMA, A.; VERMA, S.; SUDAH, S.N.; FRANKEN, P. Piriformospora indica, a cultivable plant-growth promoting root endophyte. Applied and Environmental Microbiology, v. 65, p. 2741-2744, 1999.

VEGA, F.E.; SIMPKINS, A.; AIME, M.C.; POSADA, F.; PETERSON, S.W.; REHNER, S.A.; INFANTE, F.; CASTILLO, A.; ARNOLD, A.E. Fungal endophyte diversity in coffee plants from Colombia, Hawai’i, Mexico and Puerto Rico. Fungal ecology, v. 3, p. 122-138, 2010.

XIONG, Z.Q.; YANG, Y.Y.; ZHAO, N.; WANG, Y. Diversity of endophytic fungi and screening of fungal paclitaxel producer from Anglojap yew, Taxus x media. BMC Microbiology, v. 13, n. 1, p. 1-10, 2013.

DOI: http://dx.doi.org/10.18067/jbfs.v4i2.121


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Journal of Bioenergy and Food Science

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